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Assay Detail

CHEMBL665360

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Binding
Antimycobacterial activity against Mycobacterium avium complex dihydrofolate reductase (MAC DHFR)
ChEMBL ↗
78
Total Activities
78
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mycobacterium avium
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Dihydrofolate reductase (CHEMBL5457) ↗
Type SINGLE PROTEIN
Organism Mycobacterium avium

Publication

Pharmacophore mapping of a series of 2,4-diamino-5-deazapteridine inhibitors of Mycobacterium avium complex dihydrofolate reductase.
Debnath AK.
J Med Chem (2002) 45 : 41 -53
PubMed 11754578 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 78 8.57 9.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL150470 — — 1 9.72
CHEMBL23713 — — 1 9.40
CHEMBL150317 — — 1 9.37
CHEMBL148814 — — 1 9.22
CHEMBL281648 — — 1 9.18
CHEMBL147131 — — 1 9.15
CHEMBL283518 — — 1 9.15
CHEMBL22623 — — 1 9.14
CHEMBL151367 — — 1 9.12
CHEMBL146968 — — 1 9.11
CHEMBL147256 — — 1 9.10
CHEMBL80066 — — 1 9.09
CHEMBL151674 — — 1 9.09
CHEMBL23532 — — 1 9.09
CHEMBL147124 — — 1 9.09
CHEMBL23867 — — 1 9.09
CHEMBL23416 — — 1 9.08
CHEMBL279679 — — 1 9.08
CHEMBL358884 — — 1 9.07
CHEMBL148877 — — 1 9.07
CHEMBL150082 — — 1 9.07
CHEMBL279705 — — 1 9.07
CHEMBL347061 — — 1 9.07
CHEMBL148577 — — 1 9.06
CHEMBL346666 — — 1 9.06
CHEMBL359144 — — 1 9.06
CHEMBL150382 — — 1 9.06
CHEMBL347088 — — 1 9.06
CHEMBL347974 — — 1 9.05
CHEMBL151109 — — 1 9.05

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL150470 — IC50 = 0.19 nM 9.72
CHEMBL23713 — IC50 = 0.4 nM 9.40
CHEMBL150317 — IC50 = 0.43 nM 9.37
CHEMBL148814 — IC50 = 0.6 nM 9.22
CHEMBL281648 — IC50 = 0.66 nM 9.18
CHEMBL147131 — IC50 = 0.7 nM 9.15
CHEMBL283518 — IC50 = 0.7 nM 9.15
CHEMBL22623 — IC50 = 0.73 nM 9.14
CHEMBL151367 — IC50 = 0.76 nM 9.12
CHEMBL146968 — IC50 = 0.78 nM 9.11
CHEMBL147256 — IC50 = 0.79 nM 9.10
CHEMBL151674 — IC50 = 0.82 nM 9.09
CHEMBL80066 — IC50 = 0.82 nM 9.09
CHEMBL23867 — IC50 = 0.81 nM 9.09
CHEMBL23532 — IC50 = 0.82 nM 9.09
CHEMBL147124 — IC50 = 0.82 nM 9.09
CHEMBL23416 — IC50 = 0.84 nM 9.08
CHEMBL279679 — IC50 = 0.84 nM 9.08
CHEMBL347061 — IC50 = 0.85 nM 9.07
CHEMBL279705 — IC50 = 0.86 nM 9.07
CHEMBL150082 — IC50 = 0.86 nM 9.07
CHEMBL358884 — IC50 = 0.86 nM 9.07
CHEMBL148877 — IC50 = 0.85 nM 9.07
CHEMBL347088 — IC50 = 0.87 nM 9.06
CHEMBL150382 — IC50 = 0.87 nM 9.06
CHEMBL359144 — IC50 = 0.88 nM 9.06
CHEMBL148577 — IC50 = 0.88 nM 9.06
CHEMBL346666 — IC50 = 0.87 nM 9.06
CHEMBL347974 — IC50 = 0.9 nM 9.05
CHEMBL151109 — IC50 = 0.9 nM 9.05
CHEMBL147257 — IC50 = 0.89 nM 9.05
CHEMBL147504 — IC50 = 0.91 nM 9.04
CHEMBL23383 — IC50 = 0.92 nM 9.04
CHEMBL356620 — IC50 = 0.91 nM 9.04
CHEMBL81820 — IC50 = 0.92 nM 9.04
CHEMBL81119 — IC50 = 0.91 nM 9.04
CHEMBL345258 — IC50 = 0.94 nM 9.03
CHEMBL282948 — IC50 = 0.93 nM 9.03
CHEMBL23963 — IC50 = 0.93 nM 9.03
CHEMBL151947 — IC50 = 0.93 nM 9.03
CHEMBL149273 — IC50 = 0.95 nM 9.02
CHEMBL147469 — IC50 = 0.95 nM 9.02
CHEMBL151958 — IC50 = 0.98 nM 9.01
CHEMBL151312 — IC50 = 1.0 nM 9.00
CHEMBL151451 — IC50 = 1.0 nM 9.00
CHEMBL23021 — IC50 = 1.1 nM 8.96
CHEMBL348209 — IC50 = 1.1 nM 8.96
CHEMBL345708 — IC50 = 1.1 nM 8.96
CHEMBL358195 — IC50 = 1.1 nM 8.96
CHEMBL149101 — IC50 = 1.2 nM 8.92