Assay Detail
Binding
CHEMBL665363
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Inhibition of Dihydrohydrofolate reductase(DHFR) of Mycobacterium avium
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium avium |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Further studies on 2,4-diamino-5-(2',5'-disubstituted benzyl)pyrimidines as potent and selective inhibitors of dihydrofolate reductases from three major opportunistic pathogens of AIDS.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.61 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 9.21 |
| CHEMBL34823 | — | — | 1 | 8.36 |
| CHEMBL37520 | — | — | 1 | 8.24 |
| CHEMBL37334 | — | — | 1 | 8.11 |
| CHEMBL33921 | — | — | 1 | 7.80 |
| CHEMBL285279 | — | — | 1 | 7.46 |
| CHEMBL35437 | — | — | 1 | 7.44 |
| CHEMBL33922 | — | — | 1 | 7.39 |
| CHEMBL35080 | — | — | 1 | 7.24 |
| CHEMBL290806 | — | — | 1 | 7.22 |
| CHEMBL288350 | — | — | 1 | 7.05 |
| CHEMBL288647 | — | — | 1 | 6.92 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7492 | PIRITREXIM | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL34823 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL37520 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL37334 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL33921 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL285279 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL35437 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL33922 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL35080 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL290806 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL288350 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL288647 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 300.0 | nM | 6.52 |