Assay Detail
Binding
CHEMBL665365
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Inhibitory activity against DHFR (Dihydrofolate reductase) from Mycobacterium avium
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium avium |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Structure-based design of selective inhibitors of dihydrofolate reductase: synthesis and antiparasitic activity of 2, 4-diaminopteridine analogues with a bridged diarylamine side chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.85 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301769 | — | — | 1 | 7.92 |
| CHEMBL144839 | — | — | 1 | 7.77 |
| CHEMBL144200 | — | — | 1 | 7.54 |
| CHEMBL423381 | — | — | 1 | 5.60 |
| CHEMBL424113 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301769 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL144839 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL144200 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL423381 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL424113 | — | IC50 | = | 3700.0 | nM | 5.43 |