Assay Detail
Binding
CHEMBL665411
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In vitro inhibitory activity against human dihydroorotate dehydrogenase (DHODH)
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial (CHEMBL1966) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pyrazole bioisosteres of leflunomide as B-cell immunosuppressants for xenotransplantation and chronic rejection: scope and limitations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.19 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118395 | — | — | 1 | 6.30 |
| CHEMBL334317 | — | — | 1 | 5.58 |
| CHEMBL118894 | — | — | 1 | 5.57 |
| CHEMBL119801 | — | — | 1 | 5.50 |
| CHEMBL120640 | — | — | 1 | 5.44 |
| CHEMBL118468 | — | — | 1 | 5.40 |
| CHEMBL118168 | — | — | 1 | 5.21 |
| CHEMBL418870 | — | — | 1 | 5.19 |
| CHEMBL333344 | — | — | 1 | 5.05 |
| CHEMBL330901 | — | — | 1 | 4.92 |
| CHEMBL960 | LEFLUNOMIDE | 4.0 | 1 | 4.89 |
| CHEMBL116206 | — | — | 1 | 4.78 |
| CHEMBL333404 | — | — | 1 | 4.71 |
| CHEMBL118125 | — | — | 1 | 4.65 |
| CHEMBL116946 | — | — | 1 | 4.65 |
| CHEMBL118647 | — | — | 1 | - |
| CHEMBL326960 | — | — | 1 | - |
| CHEMBL118645 | — | — | 1 | - |
| CHEMBL118489 | — | — | 1 | - |
| CHEMBL432427 | — | — | 1 | - |
| CHEMBL119564 | — | — | 1 | - |
| CHEMBL119676 | — | — | 1 | - |
| CHEMBL119193 | — | — | 1 | - |
| CHEMBL118727 | — | — | 1 | - |
| CHEMBL119780 | — | — | 1 | - |
| CHEMBL334117 | — | — | 1 | - |
| CHEMBL118499 | — | — | 1 | - |
| CHEMBL121898 | — | — | 1 | - |
| CHEMBL118455 | — | — | 1 | - |
| CHEMBL445375 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118395 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL334317 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL118894 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL119801 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL120640 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL118468 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL118168 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL418870 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL333344 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL330901 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL960 | LEFLUNOMIDE | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL116206 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL333404 | — | IC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL118125 | — | IC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL116946 | — | IC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL160 | CYCLOSPORINE | IC50 | > | 50000.0 | nM | - |
| CHEMBL118997 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL118586 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL119697 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL333276 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL332480 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL118921 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL331399 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL118647 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL326960 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL118645 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL118489 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL432427 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL119564 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL119676 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL119193 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL118727 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL119780 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL334117 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL118499 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL121898 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL118455 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL445375 | — | IC50 | > | 50000.0 | nM | - |