Assay Detail
Binding
CHEMBL665412
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In vitro inhibitory activity against human dihydroorotate dehydrogenase (DHODH)
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial (CHEMBL1966) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a novel series of DHODH inhibitors by a docking procedure and QSAR refinement.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.73 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL154623 | — | — | 1 | 8.15 |
| CHEMBL345701 | — | — | 1 | 8.10 |
| CHEMBL351786 | — | — | 1 | 7.77 |
| CHEMBL345147 | — | — | 1 | 7.75 |
| CHEMBL345464 | — | — | 1 | 7.70 |
| CHEMBL157105 | — | — | 1 | 7.48 |
| CHEMBL154121 | — | — | 1 | 7.38 |
| CHEMBL154513 | — | — | 1 | 7.35 |
| CHEMBL154151 | — | — | 1 | 7.30 |
| CHEMBL348871 | — | — | 1 | 7.16 |
| CHEMBL157164 | — | — | 1 | 7.10 |
| CHEMBL345652 | — | — | 1 | 7.05 |
| CHEMBL155597 | — | — | 1 | 6.82 |
| CHEMBL154372 | — | — | 1 | 6.77 |
| CHEMBL349577 | — | — | 1 | 6.75 |
| CHEMBL155732 | — | — | 1 | 6.65 |
| CHEMBL154493 | — | — | 1 | 6.55 |
| CHEMBL155548 | — | — | 1 | 6.54 |
| CHEMBL157277 | — | — | 1 | 6.51 |
| CHEMBL154336 | — | — | 1 | 6.43 |
| CHEMBL155530 | — | — | 1 | 6.41 |
| CHEMBL348270 | — | — | 1 | 6.39 |
| CHEMBL999 | — | — | 1 | 6.36 |
| CHEMBL154613 | — | — | 1 | 6.21 |
| CHEMBL345685 | — | — | 1 | 6.21 |
| CHEMBL345446 | — | — | 1 | 6.13 |
| CHEMBL157004 | — | — | 1 | 6.08 |
| CHEMBL347148 | — | — | 1 | 5.77 |
| CHEMBL154908 | — | — | 1 | 5.54 |
| CHEMBL154214 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL154623 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL345701 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL351786 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL345147 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL345464 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL157105 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL154121 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL154513 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL154151 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL348871 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL157164 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL345652 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL155597 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL154372 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL349577 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL155732 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL154493 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL155548 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL157277 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL154336 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL155530 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL348270 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL999 | — | IC50 | = | 435.0 | nM | 6.36 |
| CHEMBL154613 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL345685 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL345446 | — | IC50 | = | 735.0 | nM | 6.13 |
| CHEMBL157004 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL347148 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL154908 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL154214 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL358435 | — | IC50 | = | 8400.0 | nM | 5.08 |