Assay Detail
Binding
CHEMBL665591
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Inhibitory concentration against Dihydrofolate reductase from Toxoplasma gondii (tg)
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Toxoplasma gondii |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Bifunctional dihydrofolate reductase-thymidylate synthase (CHEMBL2425) ↗| Type | SINGLE PROTEIN |
| Organism | Toxoplasma gondii |
Publication
Synthesis and dihydrofolate reductase inhibitory activities of 2,4-diamino-5-deaza and 2,4-diamino-5,10-dideaza lipophilic antifolates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.77 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50514 | — | — | 1 | 9.07 |
| CHEMBL142741 | — | — | 1 | 8.05 |
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 8.00 |
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 7.96 |
| CHEMBL356490 | — | — | 1 | 7.31 |
| CHEMBL142624 | — | — | 1 | 6.70 |
| CHEMBL145068 | — | — | 1 | 6.70 |
| CHEMBL145528 | — | — | 1 | 6.60 |
| CHEMBL23288 | — | — | 1 | 6.52 |
| CHEMBL423558 | — | — | 1 | 6.33 |
| CHEMBL145691 | — | — | 1 | 5.96 |
| CHEMBL342555 | — | — | 1 | 5.96 |
| CHEMBL145169 | — | — | 1 | 5.85 |
| CHEMBL141708 | — | — | 1 | 5.85 |
| CHEMBL145005 | — | — | 1 | 5.82 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50514 | — | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL142741 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL119 | TRIMETREXATE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL7492 | PIRITREXIM | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL356490 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL142624 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL145068 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL145528 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL23288 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL423558 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL145691 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL342555 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL145169 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL141708 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL145005 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 2700.0 | nM | 5.57 |