Assay Detail
Binding
CHEMBL665593
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against Toxoplasma gondii Dihydrofolate reductase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Toxoplasma gondii |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Bifunctional dihydrofolate reductase-thymidylate synthase (CHEMBL2425) ↗| Type | SINGLE PROTEIN |
| Organism | Toxoplasma gondii |
Publication
Synthesis and biological activities of conformationally restricted, tricyclic nonclassical antifolates as inhibitors of dihydrofolate reductases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.92 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50514 | — | — | 1 | 9.07 |
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 8.00 |
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 7.77 |
| CHEMBL299927 | — | — | 1 | 6.54 |
| CHEMBL57682 | — | — | 1 | 6.28 |
| CHEMBL58597 | — | — | 1 | 6.12 |
| CHEMBL293512 | — | — | 1 | 5.95 |
| CHEMBL431740 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50514 | — | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL119 | TRIMETREXATE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL7492 | PIRITREXIM | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL299927 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL57682 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL58597 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL293512 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL431740 | — | IC50 | = | 2300.0 | nM | 5.64 |