Assay Detail
Binding
CHEMBL665594
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against Toxoplasma gondii Dihydrofolate reductase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Toxoplasma gondii |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Bifunctional dihydrofolate reductase-thymidylate synthase (CHEMBL2425) ↗| Type | SINGLE PROTEIN |
| Organism | Toxoplasma gondii |
Publication
Effect of C9-methyl substitution and C8-C9 conformational restriction on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.25 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL430872 | — | — | 1 | 5.68 |
| CHEMBL1237205 | — | — | 1 | 5.36 |
| CHEMBL104829 | FURO[2,3D]PYRIMIDINE ANTIFOLATE | — | 1 | 4.70 |
| CHEMBL2092925 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL430872 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1237205 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL104829 | FURO[2,3D]PYRIMIDINE ANTIFOLATE | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL2092925 | — | IC50 | = | 110000.0 | nM | - |