Assay Detail
Binding
CHEMBL665596
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Inhibitory concentration against Toxoplasma gondii dihydrofolate reductase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Toxoplasma gondii |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Bifunctional dihydrofolate reductase-thymidylate synthase (CHEMBL2425) ↗| Type | SINGLE PROTEIN |
| Organism | Toxoplasma gondii |
Publication
Preliminary in vitro studies on two potent, water-soluble trimethoprim analogues with exceptional species selectivity against dihydrofolate reductase from Pneumocystis carinii and Mycobacterium avium.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.08 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 8.37 |
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 7.80 |
| CHEMBL37334 | — | — | 1 | 7.50 |
| CHEMBL300419 | — | — | 1 | 7.47 |
| CHEMBL34293 | — | — | 1 | 6.47 |
| CHEMBL52415 | — | — | 1 | 6.38 |
| CHEMBL53193 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7492 | PIRITREXIM | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL119 | TRIMETREXATE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL37334 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL300419 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL34293 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL52415 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL53193 | — | IC50 | = | 2800.0 | nM | 5.55 |