Assay Detail
Binding
CHEMBL665598
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Inhibitory concentration against dihydrofolate reductase of Toxoplasma gondii
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Toxoplasma gondii |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Bifunctional dihydrofolate reductase-thymidylate synthase (CHEMBL2425) ↗| Type | SINGLE PROTEIN |
| Organism | Toxoplasma gondii |
Publication
New 2,4-diamino-5-(2',5'-substituted benzyl)pyrimidines as potential drugs against opportunistic infections of AIDS and other immune disorders. Synthesis and species-dependent antifolate activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.44 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 8.37 |
| CHEMBL35020 | — | — | 1 | 8.26 |
| CHEMBL288350 | — | — | 1 | 7.52 |
| CHEMBL284839 | — | — | 1 | 6.68 |
| CHEMBL34293 | — | — | 1 | 6.47 |
| CHEMBL35437 | — | — | 1 | 6.30 |
| CHEMBL288647 | — | — | 1 | 6.22 |
| CHEMBL289908 | — | — | 1 | 6.15 |
| CHEMBL38158 | — | — | 1 | 5.82 |
| CHEMBL35080 | — | — | 1 | 5.80 |
| CHEMBL34378 | — | — | 1 | 5.72 |
| CHEMBL290806 | — | — | 1 | 5.70 |
| CHEMBL34641 | — | — | 1 | 5.60 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7492 | PIRITREXIM | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL35020 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL288350 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL284839 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL34293 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL35437 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL288647 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL289908 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL38158 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL35080 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL34378 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL290806 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL34641 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 2800.0 | nM | 5.55 |