Assay Detail
Binding
CHEMBL665602
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The ability to inhibit Toxoplasma gondii Dihydrofolate reductase was tested
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Toxoplasma gondii |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Bifunctional dihydrofolate reductase-thymidylate synthase (CHEMBL2425) ↗| Type | SINGLE PROTEIN |
| Organism | Toxoplasma gondii |
Publication
Synthesis and antiparasitic and antitumor activity of 2, 4-diamino-6-(arylmethyl)-5,6,7,8-tetrahydroquinazoline analogues of piritrexim.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.11 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL266024 | — | — | 1 | 7.85 |
| CHEMBL268870 | — | — | 1 | 7.85 |
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 7.77 |
| CHEMBL7571 | — | — | 1 | 7.75 |
| CHEMBL268355 | — | — | 1 | 7.68 |
| CHEMBL7375 | — | — | 1 | 7.68 |
| CHEMBL267616 | — | — | 1 | 7.64 |
| CHEMBL7542 | — | — | 1 | 7.64 |
| CHEMBL7063 | — | — | 1 | 7.62 |
| CHEMBL6970 | — | — | 1 | 7.50 |
| CHEMBL7779 | — | — | 1 | 7.44 |
| CHEMBL7170 | — | — | 1 | 7.40 |
| CHEMBL7586 | — | — | 1 | 7.31 |
| CHEMBL7452 | — | — | 1 | 7.30 |
| CHEMBL7488 | — | — | 1 | 7.27 |
| CHEMBL267207 | — | — | 1 | 7.21 |
| CHEMBL7062 | — | — | 1 | 7.14 |
| CHEMBL267437 | — | — | 1 | 6.85 |
| CHEMBL7263 | — | — | 1 | 6.75 |
| CHEMBL6899 | — | — | 1 | 6.70 |
| CHEMBL7139 | — | — | 1 | 6.52 |
| CHEMBL6696 | — | — | 1 | 5.96 |
| CHEMBL7535 | — | — | 1 | 5.89 |
| CHEMBL6971 | — | — | 1 | 5.58 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL266024 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL268870 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL7492 | PIRITREXIM | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL7571 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL268355 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL7375 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL267616 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL7542 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL7063 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL6970 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL7779 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL7170 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL7586 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL7452 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL7488 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL267207 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL7062 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL267437 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL7263 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL6899 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL7139 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL6696 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL7535 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL6971 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 2700.0 | nM | 5.57 |