Assay Detail
Binding
CHEMBL665604
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against purified DHFR (Dihydrofolate reductase) from Toxoplasma gondii.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Toxoplasma gondii |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Bifunctional dihydrofolate reductase-thymidylate synthase (CHEMBL2425) ↗| Type | SINGLE PROTEIN |
| Organism | Toxoplasma gondii |
Publication
Nonclassical 2,4-diamino-6-(aminomethyl)-5,6,7,8-tetrahydroquinazoline antifolates: synthesis and biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.18 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333791 | — | — | 1 | 8.00 |
| CHEMBL120826 | — | — | 1 | 7.57 |
| CHEMBL7488 | — | — | 1 | 7.27 |
| CHEMBL121947 | — | — | 1 | 7.11 |
| CHEMBL121319 | — | — | 1 | 7.01 |
| CHEMBL120939 | — | — | 1 | 6.85 |
| CHEMBL122704 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333791 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL120826 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL7488 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL121947 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL121319 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL120939 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL122704 | — | IC50 | = | 330.0 | nM | 6.48 |