Assay Detail
Binding
CHEMBL665605
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Inhibitory activity against purified Dihydrofolate reductase from Toxoplasma gondii.
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Toxoplasma gondii |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Bifunctional dihydrofolate reductase-thymidylate synthase (CHEMBL2425) ↗| Type | SINGLE PROTEIN |
| Organism | Toxoplasma gondii |
Publication
Nonclassical 2,4-diamino-6-(aminomethyl)-5,6,7,8-tetrahydroquinazoline antifolates: synthesis and biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.64 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL123122 | — | — | 1 | 8.15 |
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 8.00 |
| CHEMBL120821 | — | — | 1 | 7.92 |
| CHEMBL121868 | — | — | 1 | 7.82 |
| CHEMBL264548 | — | — | 1 | 7.77 |
| CHEMBL121683 | — | — | 1 | 7.77 |
| CHEMBL121433 | — | — | 1 | 7.68 |
| CHEMBL123043 | — | — | 1 | 7.66 |
| CHEMBL121348 | — | — | 1 | 7.64 |
| CHEMBL123276 | — | — | 1 | 7.52 |
| CHEMBL120994 | — | — | 1 | 6.96 |
| CHEMBL7263 | — | — | 1 | 6.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL123122 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL119 | TRIMETREXATE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL120821 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL121868 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL264548 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL121683 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL121433 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL123043 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL121348 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL123276 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL120994 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL7263 | — | IC50 | = | 181.0 | nM | 6.74 |