Assay Detail

CHEMBL665683

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Functional

In vitro antiviral activity against duck hepatitis B virus (DHBV)

ChEMBL ↗

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Target

Hepatitis B virus (CHEMBL613497) ↗

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Primary target Hepatitis B virus

CHEMBL613497

Anchored from Assay target.

Protein identity Hepatitis B virus

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Hepatitis B virus
Confidence	1 — Organism
Curated By	Intermediate

Target

Hepatitis B virus (CHEMBL613497) ↗

Type	ORGANISM
Organism	Hepatitis B virus

Publication

Synthesis and antiviral activity of novel acyclic nucleoside analogues of 5-(1-azido-2-haloethyl)uracils.

Kumar R, Sharma N, Nath M, Saffran HA, Tyrrell DL.
J Med Chem (2001) 44 : 4225 -4229
PubMed 11708924 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	5.78	6.16

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1540	PENCICLOVIR	4.0	1	6.16
CHEMBL182	GANCICLOVIR	4.0	1	5.40

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1540	PENCICLOVIR	EC50	=	700.0	nM	6.16
CHEMBL182	GANCICLOVIR	EC50	=	4000.0	nM	5.40