Assay Detail
Binding
CHEMBL665700
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Inhibition of dihydrofolate reductase (DHFR) from Toxoplasma gondii(tg)
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Toxoplasma gondii |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Bifunctional dihydrofolate reductase-thymidylate synthase (CHEMBL2425) ↗| Type | SINGLE PROTEIN |
| Organism | Toxoplasma gondii |
Publication
Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase inhibitors and antitumor agents: synthesis and biological activities of 2,4-diamino-5-methyl-6-[(monosubstituted anilino)methyl] pyrido[2,3-d]pyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.91 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50514 | — | — | 1 | 9.07 |
| CHEMBL310880 | — | — | 1 | 8.27 |
| CHEMBL79922 | — | — | 1 | 8.20 |
| CHEMBL81119 | — | — | 1 | 8.15 |
| CHEMBL264386 | — | — | 1 | 8.14 |
| CHEMBL23532 | — | — | 1 | 8.13 |
| CHEMBL80070 | — | — | 1 | 8.13 |
| CHEMBL80065 | — | — | 1 | 8.02 |
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 8.00 |
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 7.96 |
| CHEMBL80066 | — | — | 1 | 7.96 |
| CHEMBL312348 | — | — | 1 | 7.92 |
| CHEMBL420224 | — | — | 1 | 7.92 |
| CHEMBL79123 | — | — | 1 | 7.77 |
| CHEMBL309966 | — | — | 1 | 7.75 |
| CHEMBL23416 | — | — | 1 | 7.72 |
| CHEMBL84457 | — | — | 1 | 7.64 |
| CHEMBL82975 | — | — | 1 | 7.57 |
| CHEMBL81820 | — | — | 1 | 7.55 |
| CHEMBL283518 | — | — | 1 | 7.54 |
| CHEMBL281803 | — | — | 1 | 7.52 |
| CHEMBL79347 | — | — | 1 | 7.52 |
| CHEMBL82924 | — | — | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50514 | — | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL310880 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL79922 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL81119 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL264386 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL23532 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL80070 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL80065 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL119 | TRIMETREXATE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL7492 | PIRITREXIM | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL80066 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL312348 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL420224 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL79123 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL309966 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL23416 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL84457 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL82975 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL81820 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL283518 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL281803 | — | IC50 | = | 30.1 | nM | 7.52 |
| CHEMBL79347 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL82924 | — | IC50 | = | 38.1 | nM | 7.42 |