Assay Detail
Functional
CHEMBL665716
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of PGE-2 generation by LPS-stimulated monocytes isolated from human blood.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-based design of cyclooxygenase-2 selectivity into ketoprofen.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.69 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL571 | KETOPROFEN | 4.0 | 1 | 7.58 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 6.96 |
| CHEMBL151128 | — | — | 1 | 6.70 |
| CHEMBL122 | ROFECOXIB | 4.0 | 1 | 6.55 |
| CHEMBL147189 | — | — | 1 | 6.11 |
| CHEMBL356596 | — | — | 1 | 6.01 |
| CHEMBL150130 | — | — | 1 | 5.75 |
| CHEMBL357262 | — | — | 1 | 5.58 |
| CHEMBL149402 | — | — | 1 | 5.30 |
| CHEMBL358210 | — | — | 1 | 5.25 |
| CHEMBL151710 | — | — | 1 | 5.25 |
| CHEMBL150340 | — | — | 1 | 5.15 |
| CHEMBL151590 | — | — | 1 | 5.08 |
| CHEMBL150363 | — | — | 1 | 5.01 |
| CHEMBL151535 | — | — | 1 | 5.01 |
| CHEMBL359202 | — | — | 1 | 4.72 |
| CHEMBL150773 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL571 | KETOPROFEN | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL118 | CELECOXIB | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL151128 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL122 | ROFECOXIB | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL147189 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL356596 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL150130 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL357262 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL149402 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL358210 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL151710 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL150340 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL151590 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL150363 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL151535 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL359202 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL150773 | — | IC50 | = | 20000.0 | nM | 4.70 |