Assay Detail
Binding
CHEMBL665718
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In vitro inhibition of the production of PGE-2 in arachidonic acid stimulated chinese hamster ovary (CHO) cells transfected with human cyclooxygenase-2
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.74 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42485 | DUP-697 | — | 1 | 8.70 |
| CHEMBL423576 | — | — | 1 | 7.92 |
| CHEMBL358609 | — | — | 1 | 7.92 |
| CHEMBL148976 | — | — | 1 | 7.85 |
| CHEMBL146742 | — | — | 1 | 7.80 |
| CHEMBL148708 | — | — | 1 | 7.80 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.58 |
| CHEMBL149040 | — | — | 1 | 6.85 |
| CHEMBL359143 | — | — | 1 | 6.38 |
| CHEMBL149936 | — | — | 1 | 6.05 |
| CHEMBL149167 | — | — | 1 | 6.00 |
| CHEMBL149076 | — | — | 1 | 5.52 |
| CHEMBL150006 | — | — | 1 | 5.49 |
| CHEMBL149597 | — | — | 1 | 5.44 |
| CHEMBL358482 | — | — | 1 | 5.30 |
| CHEMBL148666 | — | — | 1 | 5.30 |
| CHEMBL345333 | — | — | 1 | - |
| CHEMBL356206 | — | — | 1 | - |
| CHEMBL424313 | — | — | 1 | - |
| CHEMBL358666 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42485 | DUP-697 | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL423576 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL358609 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL148976 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL146742 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL148708 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL149040 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL359143 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL149936 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL149167 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL149076 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL150006 | — | IC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL149597 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL358482 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL148666 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL345333 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL356206 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL424313 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL358666 | — | IC50 | > | 5000.0 | nM | - |