Assay Detail
Binding
CHEMBL665902
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]ATRA binding to murine Cytoplasmic retinoic acid binding protein (CRABP) type 1
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Cellular retinoic acid-binding protein 1 (CHEMBL3208) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Conformationally defined 6-s-trans-retinoic acid analogs. 3. Structure-activity relationships for nuclear receptor binding, transcriptional activity, and cancer chemopreventive activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 9.07 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL46398 | — | — | 1 | 9.52 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 9.40 |
| CHEMBL333032 | — | — | 1 | 9.00 |
| CHEMBL122823 | — | — | 1 | 8.92 |
| CHEMBL121659 | — | — | 1 | 8.52 |
| CHEMBL2111792 | — | — | 1 | - |
| CHEMBL705 | ALITRETINOIN | 4.0 | 1 | - |
| CHEMBL2114968 | — | — | 1 | - |
| CHEMBL2111790 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL46398 | — | Kd | = | 0.3 | nM | 9.52 |
| CHEMBL38 | TRETINOIN | Kd | = | 0.4 | nM | 9.40 |
| CHEMBL333032 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL122823 | — | Kd | = | 1.2 | nM | 8.92 |
| CHEMBL121659 | — | Kd | = | 3.0 | nM | 8.52 |
| CHEMBL2111792 | — | Kd | > | 200.0 | nM | - |
| CHEMBL705 | ALITRETINOIN | Kd | > | 200.0 | nM | - |
| CHEMBL2114968 | — | Kd | > | 200.0 | nM | - |
| CHEMBL2111790 | — | Kd | > | 200.0 | nM | - |