Assay Detail
Binding
CHEMBL665905
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Binding affinity for mouse Cytoplasmic retinoic acid binding protein type 2
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Cellular retinoic acid-binding protein 2 (CHEMBL4172) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Conformationally defined 6-s-trans-retinoic acid analogs. 2. Selective agonists for nuclear receptor binding and transcriptional activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 8.09 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL46398 | — | — | 1 | 8.85 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 8.70 |
| CHEMBL75548 | — | — | 1 | 6.72 |
| CHEMBL72988 | — | — | 1 | - |
| CHEMBL2111557 | — | — | 2 | - |
| CHEMBL547 | ISOTRETINOIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL46398 | — | Kd | = | 1.4 | nM | 8.85 |
| CHEMBL38 | TRETINOIN | Kd | = | 2.0 | nM | 8.70 |
| CHEMBL75548 | — | Kd | = | 190.0 | nM | 6.72 |
| CHEMBL72988 | — | Kd | > | 200.0 | nM | - |
| CHEMBL2111557 | — | Kd | > | 200.0 | nM | - |
| CHEMBL547 | ISOTRETINOIN | Kd | > | 200.0 | nM | - |
| CHEMBL2111557 | — | Kd | > | 200.0 | nM | - |