Assay Detail
Binding
CHEMBL665920
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Concentration required to inhibit human Cytosolic phospholipase A2
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Pyrrolidine inhibitors of human cytosolic phospholipase A2. Part 2: synthesis of potent and crystallized 4-triphenylmethylthio derivative 'pyrrophenone'.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.18 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL385730 | — | — | 1 | 8.38 |
| CHEMBL268905 | — | — | 1 | 6.78 |
| CHEMBL281211 | ARACHIDONYL TRIFLUOROMETHYLKETONE | — | 1 | 6.38 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | - |
| CHEMBL15594 | ARACHIDONIC ACID | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL385730 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL268905 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL281211 | ARACHIDONYL TRIFLUOROMETHYLKETONE | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL6 | INDOMETHACIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL15594 | ARACHIDONIC ACID | IC50 | > | 100000.0 | nM | - |