Assay Detail

CHEMBL665982

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity was determined towards serotonin uptake site in presence of [3H]paroxetine radioligand in rat brain cortical homogenate

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Rattus norvegicus
Tissue	Brain
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).

Nichols DE, Brewster WK, Johnson MP, Oberlender R, Riggs RM.
J Med Chem (1990) 33 : 703 -710
PubMed 1967651 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	2	9.95	9.99

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL163804	—	—	1	9.99
CHEMBL43048	MIDOMAFETAMINE	3.0	1	9.91

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL163804	—	Kd	=	0.102	nM	9.99
CHEMBL43048	MIDOMAFETAMINE	Kd	=	0.123	nM	9.91