Assay Detail

CHEMBL665983

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity was determined towards serotonin uptake site in presence of [3H]paroxetine radioligand in rat hippocampal homogenate

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Rattus norvegicus
Tissue	Hippocampus
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).

Nichols DE, Brewster WK, Johnson MP, Oberlender R, Riggs RM.
J Med Chem (1990) 33 : 703 -710
PubMed 1967651 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	2	9.82	9.93

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL163804	—	—	1	9.93
CHEMBL43048	MIDOMAFETAMINE	3.0	1	9.71

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL163804	—	Kd	=	0.118	nM	9.93
CHEMBL43048	MIDOMAFETAMINE	Kd	=	0.195	nM	9.71