Assay Detail
Binding
CHEMBL666096
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cyclin D1 activated Cyclin-dependent kinase 4 (CDK4)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-based design and synthesis of 2-benzylidene-benzofuran-3-ones as flavopiridol mimics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.58 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL418203 | — | — | 1 | 6.40 |
| CHEMBL48362 | — | — | 1 | 5.73 |
| CHEMBL46181 | — | — | 1 | 5.72 |
| CHEMBL45477 | — | — | 1 | 5.66 |
| CHEMBL51709 | — | — | 1 | 5.36 |
| CHEMBL48614 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL418203 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL48362 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL46181 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL45477 | — | IC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL51709 | — | IC50 | = | 4410.0 | nM | 5.36 |
| CHEMBL48614 | — | IC50 | = | 25250.0 | nM | 4.60 |