Assay Detail
Binding
CHEMBL666097
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Inhibition of Cyclin-dependent kinase 4 (CDK4/cyclin Dl)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.06 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL142789 | — | — | 1 | 5.52 |
| CHEMBL143570 | — | — | 1 | 5.25 |
| CHEMBL290904 | — | — | 1 | 5.22 |
| CHEMBL38693 | — | — | 1 | 5.22 |
| CHEMBL40326 | — | — | 1 | 5.20 |
| CHEMBL140584 | — | — | 1 | 5.17 |
| CHEMBL142788 | — | — | 1 | 5.17 |
| CHEMBL38694 | — | — | 1 | 5.16 |
| CHEMBL40362 | — | — | 1 | 4.70 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 4.00 |
| CHEMBL280074 | OLOMOUCINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL142789 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL143570 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL290904 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL38693 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL40326 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL140584 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL142788 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL38694 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL40362 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL280074 | OLOMOUCINE | IC50 | > | 200000.0 | nM | - |