Assay Detail
Binding
CHEMBL666101
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In vitro inhibition of Cyclin-dependent kinase 4 was determined.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 1: identification and optimisation of substituted 4,6-bis anilino pyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.46 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL101119 | — | — | 1 | 7.30 |
| CHEMBL421583 | — | — | 1 | 7.00 |
| CHEMBL317378 | — | — | 1 | 6.30 |
| CHEMBL100945 | — | — | 1 | 6.10 |
| CHEMBL322640 | — | — | 1 | 6.00 |
| CHEMBL316887 | — | — | 1 | 5.70 |
| CHEMBL100811 | — | — | 1 | 5.40 |
| CHEMBL316809 | — | — | 1 | 5.30 |
| CHEMBL101557 | — | — | 1 | 5.22 |
| CHEMBL418793 | — | — | 1 | 5.10 |
| CHEMBL99647 | — | — | 1 | 5.10 |
| CHEMBL101558 | — | — | 1 | 5.05 |
| CHEMBL317281 | — | — | 1 | 4.82 |
| CHEMBL99699 | — | — | 1 | 4.75 |
| CHEMBL101868 | — | — | 1 | 4.64 |
| CHEMBL318485 | — | — | 1 | 4.57 |
| CHEMBL318188 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL101119 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL421583 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL317378 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL100945 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL322640 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL316887 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL100811 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL316809 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL101557 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL418793 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL99647 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL101558 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL317281 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL99699 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL101868 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL318485 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL318188 | — | IC50 | = | 33000.0 | nM | 4.48 |