Assay Detail
Binding
CHEMBL666103
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Inhibition of Cyclin-dependent kinase 4
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Imidazo[1,2-a]pyridines: a potent and selective class of cyclin-dependent kinase inhibitors identified through structure-based hybridisation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.46 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL102926 | — | — | 1 | 6.82 |
| CHEMBL102047 | — | — | 1 | 5.70 |
| CHEMBL72510 | — | — | 1 | 5.60 |
| CHEMBL103355 | — | — | 1 | 5.57 |
| CHEMBL72461 | — | — | 1 | 5.44 |
| CHEMBL100979 | — | — | 1 | 5.10 |
| CHEMBL99842 | — | — | 1 | 5.05 |
| CHEMBL102622 | — | — | 1 | 4.40 |
| CHEMBL317445 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL102926 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL102047 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL72510 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL103355 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL72461 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL100979 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL99842 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL102622 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL317445 | — | IC50 | > | 10000.0 | nM | - |