Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL666135

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration against Cyclin dependent kinase 1.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Cyclin-dependent kinase 1 (CHEMBL308)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

2,6,8,9-tetrasubstituted purines as new CDK1 inhibitors.
Moravec J, Krystof V, Hanus J, Havlícek L, Moravcová D, Fuksová K, Kuzma M, Lenobel R, Otyepka M, Strnad M.
Bioorg Med Chem Lett (2003) 13 : 2993 -2996
PubMed 12941319 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.34 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL102871 1 7.52
CHEMBL23327 PURVALANOLA 1 7.30
CHEMBL14762 SELICICLIB 2.0 1 6.35
CHEMBL101166 1 5.22
CHEMBL100645 1 5.10
CHEMBL99782 1 5.00
CHEMBL103272 1 4.89
CHEMBL103567 1 4.85
CHEMBL447237 1 4.80
CHEMBL100079 1 4.70
CHEMBL100670 1 4.19
CHEMBL100500 1 4.16
CHEMBL317865 1 -
CHEMBL318289 1 -
CHEMBL320873 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL102871 IC50 = 30.0 nM 7.52
CHEMBL23327 PURVALANOLA IC50 = 50.0 nM 7.30
CHEMBL14762 SELICICLIB IC50 = 450.0 nM 6.35
CHEMBL101166 IC50 = 6000.0 nM 5.22
CHEMBL100645 IC50 = 8000.0 nM 5.10
CHEMBL99782 IC50 = 10000.0 nM 5.00
CHEMBL103272 IC50 = 13000.0 nM 4.89
CHEMBL103567 IC50 = 14000.0 nM 4.85
CHEMBL447237 IC50 = 16000.0 nM 4.80
CHEMBL100079 IC50 = 20000.0 nM 4.70
CHEMBL100670 IC50 = 65000.0 nM 4.19
CHEMBL100500 IC50 = 70000.0 nM 4.16
CHEMBL317865 IC50 > 100000.0 nM -
CHEMBL318289 IC50 > 100000.0 nM -
CHEMBL320873 IC50 > 100000.0 nM -