Assay Detail
Binding
CHEMBL666141
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Inhibition of Cyclin-dependent kinase 1 (CDK1) at 12.5 uM ATP
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.31 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318999 | — | — | 1 | 8.30 |
| CHEMBL319467 | — | — | 1 | 8.02 |
| CHEMBL101801 | — | — | 1 | 7.16 |
| CHEMBL322568 | — | — | 1 | 6.66 |
| CHEMBL102636 | — | — | 1 | 6.64 |
| CHEMBL107530 | — | — | 1 | 6.10 |
| CHEMBL303958 | — | — | 1 | 5.54 |
| CHEMBL104467 | — | — | 1 | 5.28 |
| CHEMBL269881 | — | — | 1 | 5.16 |
| CHEMBL319709 | — | — | 1 | 4.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318999 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL319467 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL101801 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL322568 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL102636 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL107530 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL303958 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL104467 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL269881 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL319709 | — | IC50 | = | 63000.0 | nM | 4.20 |