Assay Detail
Binding
CHEMBL666181
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitor constant of compound for low affinity component of [3H]spiroperidol/N-propylnorapomorphine binding to Dopamine receptor D2 in absence of Gpp(NH)p
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and dopamine receptor modulating activity of spiro bicyclic peptidomimetics of L-prolyl-L-leucyl-glycinamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.85 | 7.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317488 | — | — | 1 | 7.13 |
| CHEMBL156651 | — | — | 1 | 6.72 |
| CHEMBL156164 | — | — | 1 | 6.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317488 | — | Ki | = | 73.2 | nM | 7.13 |
| CHEMBL156651 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL156164 | — | Ki | = | 196.0 | nM | 6.71 |