Assay Detail
Binding
CHEMBL666303
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for Cyclin-dependent kinase 4-cyclin D1
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 4/cyclin D1 (CHEMBL1907601) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. Part 4: Heterocycles at C3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.53 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL115706 | — | — | 1 | 8.52 |
| CHEMBL334285 | — | — | 1 | 8.40 |
| CHEMBL326961 | — | — | 1 | 8.40 |
| CHEMBL117939 | — | — | 1 | 8.30 |
| CHEMBL116619 | — | — | 1 | 8.30 |
| CHEMBL114053 | — | — | 1 | 8.15 |
| CHEMBL116934 | — | — | 1 | 8.15 |
| CHEMBL324612 | — | — | 1 | 8.10 |
| CHEMBL117473 | — | — | 1 | 8.00 |
| CHEMBL323813 | — | — | 1 | 7.92 |
| CHEMBL117647 | — | — | 1 | 7.89 |
| CHEMBL113867 | — | — | 1 | 7.82 |
| CHEMBL332712 | — | — | 1 | 7.77 |
| CHEMBL116646 | — | — | 1 | 7.68 |
| CHEMBL116331 | — | — | 1 | 7.66 |
| CHEMBL326828 | — | — | 1 | 7.66 |
| CHEMBL323908 | — | — | 1 | 7.64 |
| CHEMBL411432 | — | — | 1 | 7.64 |
| CHEMBL119106 | — | — | 1 | 7.52 |
| CHEMBL117259 | — | — | 1 | 7.52 |
| CHEMBL116670 | — | — | 1 | 7.46 |
| CHEMBL325023 | — | — | 1 | 7.34 |
| CHEMBL117712 | — | — | 1 | 7.09 |
| CHEMBL325453 | — | — | 1 | 7.08 |
| CHEMBL118027 | — | — | 1 | 7.07 |
| CHEMBL116582 | — | — | 1 | 7.05 |
| CHEMBL116510 | — | — | 1 | 6.97 |
| CHEMBL273619 | — | — | 1 | 6.90 |
| CHEMBL119493 | — | — | 1 | 6.82 |
| CHEMBL117866 | — | — | 1 | 6.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL115706 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL334285 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL326961 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL117939 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL116619 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL114053 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL116934 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL324612 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL117473 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL323813 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL117647 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL113867 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL332712 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL116646 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL326828 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL116331 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL411432 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL323908 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL119106 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL117259 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL116670 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL325023 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL117712 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL325453 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL118027 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL116582 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL116510 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL273619 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL119493 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL117866 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL117593 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL116647 | — | IC50 | = | 515.0 | nM | 6.29 |
| CHEMBL116081 | — | IC50 | = | 635.0 | nM | 6.20 |
| CHEMBL114464 | — | IC50 | > | 370.0 | nM | - |