Assay Detail
Binding
CHEMBL666305
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Inhibitory activity against Cyclin-dependent kinase 4-cyclin D1 using Rb21 as substrate
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 4/cyclin D1 (CHEMBL1907601) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Synthesis, structure-activity relationship, and biological studies of indolocarbazoles as potent cyclin D1-CDK4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.55 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62253 | — | — | 1 | 7.38 |
| CHEMBL291402 | — | — | 1 | 7.14 |
| CHEMBL293898 | — | — | 1 | 7.13 |
| CHEMBL64758 | — | — | 1 | 7.12 |
| CHEMBL59785 | — | — | 1 | 7.10 |
| CHEMBL293157 | — | — | 1 | 6.99 |
| CHEMBL64742 | — | — | 1 | 6.87 |
| CHEMBL268368 | STAUROSPORINE AGLYCON | — | 1 | 6.80 |
| CHEMBL292021 | — | — | 1 | 6.65 |
| CHEMBL304428 | — | — | 1 | 6.27 |
| CHEMBL302854 | — | — | 1 | 6.20 |
| CHEMBL61790 | — | — | 1 | 5.95 |
| CHEMBL60564 | — | — | 1 | 5.36 |
| CHEMBL432715 | — | — | 1 | 4.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62253 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL291402 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL293898 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL64758 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL59785 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL293157 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL64742 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL268368 | STAUROSPORINE AGLYCON | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL292021 | — | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL304428 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL302854 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL61790 | — | IC50 | = | 1135.0 | nM | 5.95 |
| CHEMBL60564 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL432715 | — | IC50 | = | 16200.0 | nM | 4.79 |