Assay Detail
Binding
CHEMBL666357
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Binding affinity for sigma-1 site over dopamine receptor D1 in rat using [3H]SCH-23390 as radioligand
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel (4-phenylpiperidinyl)- and (4-phenylpiperazinyl)alkyl-spaced esters of 1-phenylcyclopentanecarboxylic acids as potent sigma-selective compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.54 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL558028 | — | — | 1 | 6.19 |
| CHEMBL555580 | — | — | 1 | 6.00 |
| CHEMBL541284 | — | — | 1 | 5.54 |
| CHEMBL542630 | — | — | 1 | 5.51 |
| CHEMBL544516 | — | — | 1 | 5.31 |
| CHEMBL537464 | — | — | 1 | 5.22 |
| CHEMBL540013 | — | — | 1 | 5.00 |
| CHEMBL545678 | — | — | 1 | - |
| CHEMBL554628 | — | — | 1 | - |
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL558028 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL555580 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL541284 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL542630 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL544516 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL537464 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL540013 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL545678 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL554628 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | > | 5000.0 | nM | - |