Assay Detail
Functional
CHEMBL666387
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration to prevent formation of Coxsackievirus B3 (CVB3) plaques
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Coxsackievirus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Design, synthesis, and structure-activity relationships of pyrazolo[3,4-d]pyrimidines: a novel class of potent enterovirus inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.77 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL83909 | — | — | 1 | 7.20 |
| CHEMBL83661 | — | — | 1 | 7.14 |
| CHEMBL310618 | — | — | 1 | 7.09 |
| CHEMBL85308 | — | — | 1 | 7.08 |
| CHEMBL315945 | — | — | 1 | 7.05 |
| CHEMBL85082 | — | — | 1 | 7.02 |
| CHEMBL310633 | — | — | 1 | 6.96 |
| CHEMBL85569 | — | — | 1 | 6.96 |
| CHEMBL84696 | — | — | 1 | 6.82 |
| CHEMBL419664 | — | — | 1 | 6.77 |
| CHEMBL86169 | — | — | 1 | 6.75 |
| CHEMBL311495 | — | — | 1 | 6.58 |
| CHEMBL314939 | — | — | 1 | 6.57 |
| CHEMBL84369 | — | — | 1 | 6.52 |
| CHEMBL311922 | — | — | 1 | 6.52 |
| CHEMBL82580 | — | — | 1 | 6.51 |
| CHEMBL312411 | — | — | 1 | 6.51 |
| CHEMBL314635 | — | — | 1 | 6.31 |
| CHEMBL82701 | — | — | 1 | 6.28 |
| CHEMBL84701 | — | — | 1 | - |
| CHEMBL315687 | — | — | 1 | - |
| CHEMBL85967 | — | — | 1 | - |
| CHEMBL432570 | — | — | 1 | - |
| CHEMBL82903 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL83909 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL83661 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL310618 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL85308 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL315945 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL85082 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL310633 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL85569 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL84696 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL419664 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL86169 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL311495 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL314939 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL84369 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL311922 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL82580 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL312411 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL314635 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL82701 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL84701 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL315687 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL85967 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL432570 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL82903 | — | IC50 | > | 25000.0 | nM | - |