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Assay Detail

CHEMBL666404

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Apparent inhibition constant (Ki) Cytochrome P450 19A1
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Aromatase (CHEMBL1978)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Time-dependent inactivation of aromatase by 6-alkylandrosta-1,4-diene-3,17-diones. Effects of length and configuration of 6-alkyl group.
Numazawa M, Oshibe M, Yamaguchi S, Tachibana M.
J Med Chem (1996) 39 : 1033 -1038
PubMed 8676338 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 7.82 8.33

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL8313 1 8.33
CHEMBL440832 1 8.30
CHEMBL8254 1 8.15
CHEMBL268918 1 8.11
CHEMBL266350 1 8.10
CHEMBL267668 1 7.96
CHEMBL8417 1 7.85
CHEMBL8646 1 7.80
CHEMBL8498 1 7.72
CHEMBL268209 1 7.70
CHEMBL8333 1 7.66
CHEMBL266532 1 7.60
CHEMBL1078534 ANDROSTENEDONE 1 7.37
CHEMBL8315 1 7.37
CHEMBL274878 1 7.27

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL8313 Ki = 4.7 nM 8.33
CHEMBL440832 Ki = 5.0 nM 8.30
CHEMBL8254 Ki = 7.0 nM 8.15
CHEMBL268918 Ki = 7.8 nM 8.11
CHEMBL266350 Ki = 8.0 nM 8.10
CHEMBL267668 Ki = 11.0 nM 7.96
CHEMBL8417 Ki = 14.0 nM 7.85
CHEMBL8646 Ki = 16.0 nM 7.80
CHEMBL8498 Ki = 19.0 nM 7.72
CHEMBL268209 Ki = 20.0 nM 7.70
CHEMBL8333 Ki = 22.0 nM 7.66
CHEMBL266532 Ki = 25.0 nM 7.60
CHEMBL1078534 ANDROSTENEDONE Ki = 43.0 nM 7.37
CHEMBL8315 Ki = 43.0 nM 7.37
CHEMBL274878 Ki = 54.0 nM 7.27