Assay Detail

CHEMBL666405

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Binding

Inhibitory constant (Ki) for Cytochrome P450 19A1

ChEMBL ↗

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Target

Aromatase (CHEMBL1978) ↗

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Primary target Aromatase

CHEMBL1978

Anchored from Assay target.

Protein identity Aromatase

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Expert

Target

Aromatase (CHEMBL1978) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Analogues of aminoglutethimide: selective inhibition of aromatase.

Foster AB, Jarman M, Leung CS, Rowlands MG, Taylor GN, Plevey RG, Sampson P.
J Med Chem (1985) 28 : 200 -204
PubMed 3968684 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	2	6.09	6.22

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL488	AMINOGLUTETHIMIDE	4.0	1	6.22
CHEMBL289116	ROGLETIMIDE	2.0	1	5.96

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL488	AMINOGLUTETHIMIDE	Ki	=	600.0	nM	6.22
CHEMBL289116	ROGLETIMIDE	Ki	=	1100.0	nM	5.96