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Assay Detail

CHEMBL666573

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibition of human Dipeptidylpeptidase IV.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Dipeptidyl peptidase 4 (CHEMBL284)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Development of potent and selective dipeptidyl peptidase II inhibitors.
Senten K, Van der Veken P, Bal G, De Meester I, Lambeir AM, Scharpé S, Bauvois B, Haemers A, Augustyns K.
Bioorg Med Chem Lett (2002) 12 : 2825 -2828
PubMed 12270155 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 4.75 5.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL503274 1 5.40
CHEMBL383705 1 5.40
CHEMBL317126 1 4.85
CHEMBL403882 1 4.82
CHEMBL98008 1 4.77
CHEMBL93931 1 4.68
CHEMBL317944 1 4.63
CHEMBL328694 1 4.41
CHEMBL443622 1 4.39
CHEMBL93507 1 4.17
CHEMBL328655 1 -
CHEMBL328795 1 -
CHEMBL97674 1 -
CHEMBL93505 1 -
CHEMBL329171 1 -
CHEMBL94955 1 -
CHEMBL97180 1 -
CHEMBL97025 1 -
CHEMBL97064 1 -
CHEMBL499101 1 -
CHEMBL93558 1 -
CHEMBL317537 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL503274 IC50 = 4000.0 nM 5.40
CHEMBL383705 IC50 = 4000.0 nM 5.40
CHEMBL317126 IC50 = 14000.0 nM 4.85
CHEMBL403882 IC50 = 15000.0 nM 4.82
CHEMBL98008 IC50 = 17000.0 nM 4.77
CHEMBL93931 IC50 = 21000.0 nM 4.68
CHEMBL317944 IC50 = 23210.0 nM 4.63
CHEMBL328694 IC50 = 39000.0 nM 4.41
CHEMBL443622 IC50 = 41000.0 nM 4.39
CHEMBL93507 IC50 = 67000.0 nM 4.17
CHEMBL328655 IC50 > 500000.0 nM -
CHEMBL328795 IC50 = 188000.0 nM -
CHEMBL97674 IC50 = 247000.0 nM -
CHEMBL93505 IC50 > 1000000.0 nM -
CHEMBL329171 IC50 > 500000.0 nM -
CHEMBL94955 IC50 = 134900.0 nM -
CHEMBL97180 IC50 = 213000.0 nM -
CHEMBL97025 IC50 > 1000000.0 nM -
CHEMBL97064 IC50 = 190000.0 nM -
CHEMBL499101 IC50 = 122000.0 nM -
CHEMBL93558 IC50 = 217000.0 nM -
CHEMBL317537 IC50 > 1000000.0 nM -