Assay Detail
Binding
CHEMBL666606
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Inhibitory activity against baculovirus expressed Cyclin dependent kinase 4-cyclinD1
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 4/cyclin D1 (CHEMBL1907601) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.87 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL126630 | — | — | 1 | 7.52 |
| CHEMBL300936 | — | — | 1 | 7.00 |
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 6.82 |
| CHEMBL126997 | — | — | 1 | 6.41 |
| CHEMBL126328 | — | — | 1 | 6.19 |
| CHEMBL295136 | — | — | 1 | 6.16 |
| CHEMBL340794 | — | — | 1 | 6.05 |
| CHEMBL48796 | — | — | 1 | 6.02 |
| CHEMBL129471 | — | — | 1 | 5.97 |
| CHEMBL126993 | — | — | 1 | 5.97 |
| CHEMBL129396 | — | — | 1 | 5.96 |
| CHEMBL125401 | — | — | 1 | 5.65 |
| CHEMBL126908 | — | — | 1 | 5.52 |
| CHEMBL2111846 | — | — | 1 | 5.50 |
| CHEMBL263955 | — | — | 1 | 5.46 |
| CHEMBL125731 | — | — | 1 | 5.35 |
| CHEMBL420143 | — | — | 1 | 5.29 |
| CHEMBL340012 | — | — | 1 | 5.27 |
| CHEMBL339246 | — | — | 1 | 4.72 |
| CHEMBL127929 | — | — | 1 | 4.64 |
| CHEMBL126549 | — | — | 1 | - |
| CHEMBL126782 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL126630 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL300936 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL126997 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL126328 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL295136 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL340794 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL48796 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL129471 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL126993 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL129396 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL125401 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL126908 | — | IC50 | = | 2990.0 | nM | 5.52 |
| CHEMBL2111846 | — | IC50 | = | 3130.0 | nM | 5.50 |
| CHEMBL263955 | — | IC50 | = | 3480.0 | nM | 5.46 |
| CHEMBL125731 | — | IC50 | = | 4510.0 | nM | 5.35 |
| CHEMBL420143 | — | IC50 | = | 5160.0 | nM | 5.29 |
| CHEMBL340012 | — | IC50 | = | 5380.0 | nM | 5.27 |
| CHEMBL339246 | — | IC50 | = | 19060.0 | nM | 4.72 |
| CHEMBL127929 | — | IC50 | = | 23030.0 | nM | 4.64 |
| CHEMBL126549 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL126782 | — | IC50 | > | 25000.0 | nM | - |