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Assay Detail

CHEMBL666660

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Binding
Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)
ChEMBL ↗
75
Total Activities
75
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Gallus gallus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Dihydrofolate reductase (CHEMBL2575) ↗
Type SINGLE PROTEIN
Organism Gallus gallus

Publication

Crystallography, quantitative structure-activity relationships, and molecular graphics in a comparative analysis of the inhibition of dihydrofolate reductase from chicken liver and Lactobacillus casei by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazine s.
Hansch C, Hathaway BA, Guo ZR, Selassie CD, Dietrich SW, Blaney JM, Langridge R, Volz KW, Kaufman BT.
J Med Chem (1984) 27 : 129 -143
PubMed 6420569 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 75 6.61 8.17

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL31004 — — 1 8.17
CHEMBL283173 — — 1 7.71
CHEMBL20224 — — 1 7.70
CHEMBL20812 — — 1 7.64
CHEMBL283740 — — 1 7.59
CHEMBL6671 — — 1 7.54
CHEMBL7191 — — 1 7.53
CHEMBL20975 — — 1 7.52
CHEMBL30681 — — 1 7.49
CHEMBL21031 — — 1 7.47
CHEMBL268414 — — 1 7.44
CHEMBL283916 — — 1 7.40
CHEMBL6962 — — 1 7.38
CHEMBL34627 — — 1 7.30
CHEMBL282754 — — 1 7.28
CHEMBL282932 — — 1 7.27
CHEMBL33558 — — 1 7.24
CHEMBL34274 — — 1 7.19
CHEMBL21258 — — 1 7.18
CHEMBL7035 — — 1 7.14
CHEMBL285019 — — 1 7.13
CHEMBL6741 — — 1 7.12
CHEMBL32063 — — 1 7.12
CHEMBL7004 — — 1 7.09
CHEMBL7070 — — 1 7.08
CHEMBL287436 — — 1 7.05
CHEMBL6948 — — 1 7.01
CHEMBL20874 — — 1 7.00
CHEMBL20368 — — 1 6.98
CHEMBL747 CYCLOGUANIL 2.0 1 6.95

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL31004 — Ki = 6.761 nM 8.17
CHEMBL283173 — Ki = 19.5 nM 7.71
CHEMBL20224 — Ki = 19.95 nM 7.70
CHEMBL20812 — Ki = 22.91 nM 7.64
CHEMBL283740 — Ki = 25.7 nM 7.59
CHEMBL6671 — Ki = 28.84 nM 7.54
CHEMBL7191 — Ki = 29.51 nM 7.53
CHEMBL20975 — Ki = 30.2 nM 7.52
CHEMBL30681 — Ki = 32.36 nM 7.49
CHEMBL21031 — Ki = 33.88 nM 7.47
CHEMBL268414 — Ki = 36.31 nM 7.44
CHEMBL283916 — Ki = 39.81 nM 7.40
CHEMBL6962 — Ki = 41.69 nM 7.38
CHEMBL34627 — Ki = 50.12 nM 7.30
CHEMBL282754 — Ki = 52.48 nM 7.28
CHEMBL282932 — Ki = 53.7 nM 7.27
CHEMBL33558 — Ki = 57.54 nM 7.24
CHEMBL34274 — Ki = 64.57 nM 7.19
CHEMBL21258 — Ki = 66.07 nM 7.18
CHEMBL7035 — Ki = 72.44 nM 7.14
CHEMBL285019 — Ki = 74.13 nM 7.13
CHEMBL6741 — Ki = 75.86 nM 7.12
CHEMBL32063 — Ki = 75.86 nM 7.12
CHEMBL7004 — Ki = 81.28 nM 7.09
CHEMBL7070 — Ki = 83.18 nM 7.08
CHEMBL287436 — Ki = 89.13 nM 7.05
CHEMBL6948 — Ki = 97.72 nM 7.01
CHEMBL20874 — Ki = 100.0 nM 7.00
CHEMBL20368 — Ki = 104.71 nM 6.98
CHEMBL747 CYCLOGUANIL Ki = 112.2 nM 6.95
CHEMBL20861 — Ki = 112.2 nM 6.95
CHEMBL268914 — Ki = 114.82 nM 6.94
CHEMBL7341 — Ki = 117.49 nM 6.93
CHEMBL7357 — Ki = 117.49 nM 6.93
CHEMBL7005 — Ki = 128.82 nM 6.89
CHEMBL20424 — Ki = 162.18 nM 6.79
CHEMBL267499 — Ki = 162.18 nM 6.79
CHEMBL269704 — Ki = 165.96 nM 6.78
CHEMBL427826 — Ki = 169.82 nM 6.77
CHEMBL30370 — Ki = 169.82 nM 6.77
CHEMBL33389 — Ki = 173.78 nM 6.76
CHEMBL267692 — Ki = 177.83 nM 6.75
CHEMBL20922 — Ki = 194.98 nM 6.71
CHEMBL6661 — Ki = 194.98 nM 6.71
CHEMBL6742 — Ki = 204.17 nM 6.69
CHEMBL20129 — Ki = 281.84 nM 6.55
CHEMBL20587 — Ki = 295.12 nM 6.53
CHEMBL32304 — Ki = 316.23 nM 6.50
CHEMBL414610 — Ki = 316.23 nM 6.50
CHEMBL266573 — Ki = 331.13 nM 6.48