Assay Detail
Binding
CHEMBL666727
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against relaxation activity of DNA topoisomerase II by detecting the conversion of supercoiled pBR322 DNA to its relaxed form
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Inhibitory activities against topoisomerase I and II by polyhydroxybenzoyl amide derivatives and their structure-activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.18 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL47027 | — | — | 1 | 8.05 |
| CHEMBL47885 | — | — | 1 | 6.82 |
| CHEMBL47526 | — | — | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL47027 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL47885 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL47526 | — | IC50 | = | 220.0 | nM | 6.66 |