Assay Detail
Binding
CHEMBL666745
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Compound was evaluated for 50% inhibition of Cyclin-dependent kinase 4-cyclin D1
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 4/cyclin D1 (CHEMBL1907601) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 2. Probing the indeno ring substituent pattern.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 6.31 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL345525 | — | — | 1 | 8.05 |
| CHEMBL147038 | — | — | 1 | 7.92 |
| CHEMBL147012 | — | — | 1 | 7.92 |
| CHEMBL357770 | — | — | 1 | 7.92 |
| CHEMBL149834 | — | — | 1 | 7.70 |
| CHEMBL148580 | — | — | 1 | 7.58 |
| CHEMBL148889 | — | — | 1 | 7.19 |
| CHEMBL346164 | — | — | 1 | 7.18 |
| CHEMBL346184 | — | — | 1 | 7.12 |
| CHEMBL147084 | — | — | 1 | 7.09 |
| CHEMBL151915 | — | — | 1 | 6.95 |
| CHEMBL357491 | — | — | 1 | 6.90 |
| CHEMBL434081 | — | — | 1 | 6.71 |
| CHEMBL358281 | — | — | 1 | 6.51 |
| CHEMBL147281 | — | — | 1 | 6.34 |
| CHEMBL27275 | — | — | 1 | 6.32 |
| CHEMBL149705 | — | — | 1 | 6.11 |
| CHEMBL436078 | — | — | 1 | 6.06 |
| CHEMBL151720 | — | — | 1 | 6.05 |
| CHEMBL341835 | — | — | 1 | 6.04 |
| CHEMBL147290 | — | — | 1 | 5.94 |
| CHEMBL357330 | — | — | 1 | 4.70 |
| CHEMBL151616 | — | — | 1 | 4.67 |
| CHEMBL147254 | — | — | 1 | 4.64 |
| CHEMBL357986 | — | — | 1 | 4.46 |
| CHEMBL281470 | — | — | 1 | 4.35 |
| CHEMBL355951 | — | — | 1 | 4.26 |
| CHEMBL147523 | — | — | 1 | 4.10 |
| CHEMBL148652 | — | — | 1 | - |
| CHEMBL150529 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL345525 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL147038 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL357770 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL147012 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL149834 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL148580 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL148889 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL346164 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL346184 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL147084 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL151915 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL357491 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL434081 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL358281 | — | IC50 | = | 307.0 | nM | 6.51 |
| CHEMBL147281 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL27275 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL149705 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL436078 | — | IC50 | = | 877.0 | nM | 6.06 |
| CHEMBL151720 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL341835 | — | IC50 | = | 917.0 | nM | 6.04 |
| CHEMBL147290 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL357330 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL151616 | — | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL147254 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL357986 | — | IC50 | = | 34500.0 | nM | 4.46 |
| CHEMBL281470 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL355951 | — | IC50 | = | 55500.0 | nM | 4.26 |
| CHEMBL147523 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL149884 | — | IC50 | > | 2300.0 | nM | - |
| CHEMBL151696 | — | IC50 | = | 108000.0 | nM | - |
| CHEMBL424507 | — | IC50 | > | 1400.0 | nM | - |
| CHEMBL149956 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL355993 | — | IC50 | > | 361000.0 | nM | - |
| CHEMBL357142 | — | IC50 | > | 340000.0 | nM | - |
| CHEMBL149095 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL151551 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL358390 | — | IC50 | > | 1100.0 | nM | - |
| CHEMBL150529 | — | IC50 | > | 1300.0 | nM | - |
| CHEMBL148652 | — | IC50 | > | 150000.0 | nM | - |