Assay Detail
Binding
CHEMBL666790
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Inhibition of human placental microsome cytochrome P450 19A1 aromatase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.33 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9298 | FADROZOLE | 2.0 | 1 | 7.28 |
| CHEMBL158984 | — | — | 1 | 7.00 |
| CHEMBL161230 | — | — | 1 | 6.62 |
| CHEMBL350922 | — | — | 1 | 6.41 |
| CHEMBL158635 | — | — | 1 | 6.26 |
| CHEMBL351167 | — | — | 1 | 5.96 |
| CHEMBL161530 | — | — | 1 | 5.68 |
| CHEMBL157925 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9298 | FADROZOLE | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL158984 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL161230 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL350922 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL158635 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL351167 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL161530 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL157925 | — | IC50 | = | 3700.0 | nM | 5.43 |