Assay Detail
Binding
CHEMBL666792
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In vitro inhibitory activity against Cytochrome P450 19A1 using human placental microsomes.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tetrahydronaphthalenes: influence of heterocyclic substituents on inhibition of steroid enzymes P450 arom and P450 17.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.03 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL352645 | — | — | 1 | 6.22 |
| CHEMBL168444 | — | — | 1 | 4.57 |
| CHEMBL353068 | — | — | 1 | 4.29 |
| CHEMBL169449 | — | — | 1 | - |
| CHEMBL169664 | — | — | 1 | - |
| CHEMBL168762 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL352645 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL168444 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL353068 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL169449 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL169664 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL168762 | — | IC50 | > | 250000.0 | nM | - |