Assay Detail
Binding
CHEMBL666795
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human placental microsome cytochrome P450 19A1 aromatase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.32 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159073 | — | — | 1 | 7.40 |
| CHEMBL421149 | — | — | 1 | 7.37 |
| CHEMBL421829 | — | — | 1 | 7.05 |
| CHEMBL78322 | — | — | 1 | 6.03 |
| CHEMBL307160 | — | — | 1 | 6.01 |
| CHEMBL442373 | — | — | 1 | 5.64 |
| CHEMBL488 | AMINOGLUTETHIMIDE | 4.0 | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159073 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL421149 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL421829 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL78322 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL307160 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL442373 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL488 | AMINOGLUTETHIMIDE | IC50 | = | 18500.0 | nM | 4.73 |