Assay Detail
Binding
CHEMBL666797
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of [1,2,6,7-3H]-androstenedione binding to human placental microsome cytochrome P450 19A1
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
New aromatase inhibitors. Synthesis and inhibitory activity of pyridinyl-substituted flavanone derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.50 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10137 | — | — | 1 | 6.21 |
| CHEMBL10026 | — | — | 1 | 6.10 |
| CHEMBL267508 | — | — | 1 | 5.80 |
| CHEMBL10072 | — | — | 1 | 5.48 |
| CHEMBL488 | AMINOGLUTETHIMIDE | 4.0 | 1 | 5.28 |
| CHEMBL9687 | — | — | 1 | 5.10 |
| CHEMBL274318 | FLAVANONE | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10137 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL10026 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL267508 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL10072 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL488 | AMINOGLUTETHIMIDE | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL9687 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL274318 | FLAVANONE | IC50 | = | 28500.0 | nM | 4.54 |