Assay Detail
Binding
CHEMBL666801
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Inhibition of 1 uM [1-beta-3H]-androstenedione binding to human placental microsome Cytochrome P450 19A1
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biochemical studies of 16- or 19-substituted androst-4-enes as aromatase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.25 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1629805 | — | — | 1 | 6.57 |
| CHEMBL132530 | FORMESTANE | 2.0 | 1 | 6.39 |
| CHEMBL1629804 | — | — | 1 | 6.28 |
| CHEMBL83835 | — | — | 1 | 5.92 |
| CHEMBL440691 | — | — | 1 | 5.64 |
| CHEMBL309656 | — | — | 1 | 5.40 |
| CHEMBL83422 | — | — | 1 | 5.39 |
| CHEMBL81134 | — | — | 1 | 5.23 |
| CHEMBL439950 | — | — | 1 | 5.14 |
| CHEMBL2112309 | — | — | 1 | 4.58 |
| CHEMBL311077 | — | — | 1 | 4.42 |
| CHEMBL443530 | — | — | 1 | 4.36 |
| CHEMBL82981 | — | — | 1 | 4.21 |
| CHEMBL81255 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1629805 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL132530 | FORMESTANE | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL1629804 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL83835 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL440691 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL309656 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL83422 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL81134 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL439950 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL2112309 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL311077 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL443530 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL82981 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL81255 | — | IC50 | = | 100000.0 | nM | 4.00 |