Assay Detail
Binding
CHEMBL666806
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Leu22-Phe mutant human Dihydrofolate reductase
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2,4-Diamino-5-substituted-quinazolines as inhibitors of a human dihydrofolate reductase with a site-directed mutation at position 22 and of the dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 8.09 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305177 | — | — | 1 | 11.00 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 9.96 |
| CHEMBL376180 | AMINOPTERIN | 2.0 | 1 | 9.68 |
| CHEMBL164845 | — | — | 1 | 8.74 |
| CHEMBL162476 | — | — | 1 | 8.57 |
| CHEMBL341703 | — | — | 1 | 8.54 |
| CHEMBL349149 | — | — | 1 | 8.38 |
| CHEMBL441298 | — | — | 1 | 8.37 |
| CHEMBL350730 | — | — | 1 | 7.48 |
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 7.42 |
| CHEMBL162270 | — | — | 1 | 7.31 |
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 7.08 |
| CHEMBL355151 | — | — | 1 | 7.02 |
| CHEMBL162312 | — | — | 1 | 6.85 |
| CHEMBL434097 | — | — | 1 | 6.60 |
| CHEMBL165955 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305177 | — | Ki | = | 0.01 | nM | 11.00 |
| CHEMBL34259 | METHOTREXATE | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL376180 | AMINOPTERIN | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL164845 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL162476 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL341703 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL349149 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL441298 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL350730 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL7492 | PIRITREXIM | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL162270 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL119 | TRIMETREXATE | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL355151 | — | Ki | = | 96.3 | nM | 7.02 |
| CHEMBL162312 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL434097 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL165955 | — | Ki | = | 310.0 | nM | 6.51 |