Assay Detail
Binding
CHEMBL666971
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards Chinese hamster ovary cells transfected with human D3 receptor using [3H]spiperone
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | ovary |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A novel series of arylpiperazines with high affinity and selectivity for the dopamine D3 receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.97 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL73665 | — | — | 1 | 9.70 |
| CHEMBL294747 | — | — | 1 | 9.50 |
| CHEMBL423671 | — | — | 1 | 9.50 |
| CHEMBL71960 | — | — | 1 | 9.30 |
| CHEMBL70866 | — | — | 1 | 8.50 |
| CHEMBL71894 | — | — | 1 | 8.20 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL73665 | — | Ki | = | 0.1995 | nM | 9.70 |
| CHEMBL294747 | — | Ki | = | 0.3162 | nM | 9.50 |
| CHEMBL423671 | — | Ki | = | 0.3162 | nM | 9.50 |
| CHEMBL71960 | — | Ki | = | 0.5012 | nM | 9.30 |
| CHEMBL70866 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL71894 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 7.943 | nM | 8.10 |