Assay Detail
Binding
CHEMBL666992
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Inhibitory concentration against dihydrofolate reductase of Mycobacterium avium
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium avium |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
New 2,4-diamino-5-(2',5'-substituted benzyl)pyrimidines as potential drugs against opportunistic infections of AIDS and other immune disorders. Synthesis and species-dependent antifolate activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.68 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34775 | — | — | 1 | 9.72 |
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 9.21 |
| CHEMBL38053 | — | — | 1 | 9.19 |
| CHEMBL35020 | — | — | 1 | 8.82 |
| CHEMBL34293 | — | — | 1 | 8.43 |
| CHEMBL284839 | — | — | 1 | 7.60 |
| CHEMBL38158 | — | — | 1 | 7.60 |
| CHEMBL35437 | — | — | 1 | 7.44 |
| CHEMBL35080 | — | — | 1 | 7.24 |
| CHEMBL290806 | — | — | 1 | 7.22 |
| CHEMBL288350 | — | — | 1 | 7.05 |
| CHEMBL34378 | — | — | 1 | 7.00 |
| CHEMBL288647 | — | — | 1 | 6.92 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 6.52 |
| CHEMBL289908 | — | — | 1 | 6.51 |
| CHEMBL34641 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34775 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL7492 | PIRITREXIM | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL38053 | — | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL35020 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL34293 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL284839 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL38158 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL35437 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL35080 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL290806 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL288350 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL34378 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL288647 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL289908 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL34641 | — | IC50 | = | 380.0 | nM | 6.42 |