Assay Detail
Binding
CHEMBL667003
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In vitro inhibition of dihydrofolate reductase enzymes in Neisseria gonorrhoeae
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Lacticaseibacillus casei |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Dihydrofolate reductase (CHEMBL4012) ↗| Type | SINGLE PROTEIN |
| Organism | Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcuslactis) |
Publication
2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 13. Some alkenyl derivatives with high in vitro activity against anaerobic organisms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.16 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23746 | — | — | 1 | 7.70 |
| CHEMBL24503 | — | — | 1 | 7.70 |
| CHEMBL59470 | — | — | 1 | 7.54 |
| CHEMBL60821 | — | — | 1 | 7.48 |
| CHEMBL301030 | — | — | 1 | 7.44 |
| CHEMBL58550 | — | — | 1 | 7.39 |
| CHEMBL279455 | — | — | 1 | 7.36 |
| CHEMBL301236 | — | — | 1 | 7.32 |
| CHEMBL26337 | — | — | 1 | 7.22 |
| CHEMBL59416 | — | — | 1 | 7.18 |
| CHEMBL278345 | — | — | 1 | 7.17 |
| CHEMBL60069 | — | — | 1 | 7.10 |
| CHEMBL23338 | — | — | 1 | 7.03 |
| CHEMBL282022 | — | — | 1 | 6.95 |
| CHEMBL303075 | — | — | 1 | 6.85 |
| CHEMBL59946 | — | — | 1 | 6.83 |
| CHEMBL23609 | — | — | 1 | 6.77 |
| CHEMBL412892 | — | — | 1 | 6.59 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23746 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL24503 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL59470 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL60821 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL301030 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL58550 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL279455 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL301236 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL26337 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL59416 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL278345 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL60069 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL23338 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL282022 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL303075 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL59946 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL23609 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL412892 | — | IC50 | = | 255.0 | nM | 6.59 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 450.0 | nM | 6.35 |