Assay Detail
Binding
CHEMBL667313
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Binding affinity towards Dihydrofolate reductase derived from L1210 cells using [3H]- MTX as the radioligand
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | L1210 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and antifolate properties of 9-alkyl-10-deazaminopterins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.71 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296373 | EDATREXATE | 2.0 | 1 | 6.00 |
| CHEMBL293263 | — | — | 1 | 5.92 |
| CHEMBL431359 | — | — | 1 | 5.52 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296373 | EDATREXATE | Ki | = | 990.0 | nM | 6.00 |
| CHEMBL293263 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL431359 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL34259 | METHOTREXATE | Ki | = | 3900.0 | nM | 5.41 |